SR 9243

Cat. No. 6138new

SR 9243 C31H32BrNO4S2 [1613028-81-1]

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Chemical Name: N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide

Biological Activity

Selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.

Technical Data

M.Wt:
626.62
Formula:
C31H32BrNO4S2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1613028-81-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Flaveny et al (2015) Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 28 42. PMID: 26120082.

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Keywords: SR 9243, supplier, SR9243, selective, LXR, inverse, agonists, agonism, lipogenesis, Warburg, effect, Tocris Bioscience, LXR-like Receptor Antagonist products

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