Cat. No. 2689
Alternative Name: Sodium polyoxotungstate
Chemical Name: Sodium metatungstate
Biological ActivityInhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
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References are publications that support the products' biological activity.
Wall et al (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. 55 1251. PMID: 18768144.
Grenz et al (2007) Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21 2863. PMID: 17442731.
Muller et al (2006) Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 16 5943. PMID: 16997558.
If you know of a relevant reference for POM 1 please let us know.
Citations are publications that use Tocris products. Selected citations for POM 1 include:
Del Papa et al (2016) The NOTCH1/CD39 axis: a Treg trip-switch for GvHD. Leukemia 30 1931. PMID: 27125307.
Fang et al (2016) Expression of CD39 on activated T cells impairs their survival in older individuals. Cell Rep. 14 1218. PMID: 26832412.
Rao et al (2014) A dual role for autophagy in a murine model of lung cancer. Cancer Biol Ther 5 3056. PMID: 24445999.
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70. PMID: 24047499.
Yegutkin et al (2012) Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J 26 3875. PMID: 22637533.
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Keywords: POM 1, supplier, inhibitors, inhibits, E-NTPDases, ATPases, POM1, Tocris Bioscience, NTPDase Inhibitor products
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