Cat. No. 2685
Alternative Name: BM 14190
Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-me
Biological ActivityPotent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kikuta et al (2006) Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 529 47. PMID: 16325804.
Ponicke et al (2002) Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71. PMID: 11907159.
Ohlstein et al (1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc.Natl.Acad.Sci.USA. 90 6189.
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Citations are publications that use Tocris products. Selected citations for Carvedilol include:
Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486. PMID: 21865315.
Ajmo et al (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Nat Commun 218 47. PMID: 19371742.
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Keywords: Carvedilol, supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, β-adrenergic, beta-adrenergic, b-adrenergic, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, Non-Selective, Adrenoceptors, BM14190, Tocris Bioscience, Non-selective Adrenergic β Receptor Antagonist products
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