CYN 154806

Cat. No. 1843

CYN 154806 Ac-(4-Nitro)Phe-D-Cys-Tyr-D-Trp-Lys-Thr-Cys-D-Tyr-NH2 (Disulfide bridge: 2 - 7)

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Biological Activity

Potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

Technical Data

M.Wt:
1197.35
Formula:
C56H68N12O14S2
Sequence:
FCYWKTCY

(Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge between 2 - 7)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
183658-72-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15. PMID: 11931345.

Feniuk et al (2000) Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 39 1443. PMID: 10818260.

Bass et al (1996) Identification and characterization of novel somatostatin antagonists. Mol.Pharmacol. 50 709. PMID: 8863814.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CYN 154806 include:

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130. PMID: 25406263.

Iwagaki et al (2013) Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse. Mol Pain 9 56. PMID: 24176114.

Do you know of a great paper that uses CYN 154806 from Tocris? If so please let us know.

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Keywords: CYN 154806, supplier, Selective, sst2, antagonists, Receptors, Somatostatin, CYN154806, Tocris Bioscience, Somatostatin (sst) Receptor Antagonist products

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