CL 82198 hydrochloride
Cat. No. 2632
Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzof
Biological ActivitySelective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122.
Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for CL 82198 hydrochloride include:
Wang et al (2013) MMP13 is a critical target gene during the progression of osteoarthritis. J Neurosci 15 R5. PMID: 23298463.
Do you know of a great paper that uses CL 82198 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CL 82198 hydrochloride, supplier, Selective, inhibitors, inhibits, MMP-13, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, CL82198, hydrochloride, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.