CL 82198 hydrochloride

Cat. No. 2632

CL 82198 hydrochloride C17H23N2O3.HCl [1188890-36-9]

Price and Availability

For CL 82198 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

Biological Activity

Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.

Technical Data

M.Wt:
338.83
Formula:
C17H23N2O3.HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1188890-36-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122.

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CL 82198 hydrochloride include:

Wang et al (2013) MMP13 is a critical target gene during the progression of osteoarthritis. J Neurosci 15 R5. PMID: 23298463.

Do you know of a great paper that uses CL 82198 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CL 82198 hydrochloride, supplier, Selective, inhibitors, inhibits, MMP-13, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, CL82198, hydrochloride, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

New Products in this Area

(R)-MG 132

Potent 20S proteasome inhibitor

Diprotin A

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Acein

High affinity angiotensin-converting enzyme (ACE) ligand

TMI 1

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Ritonavir

HIV-1 and HIV-2 protease inhibitor

Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2016

Pharmacology 2016

December 13 - 15, 2016

London, UK

Booth: 7