Cat. No. 2681
Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
Biological ActivitySelective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Akk et al (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. Mol.Pharmacol. 71 461. PMID: 17105870.
Kelley et al (2007) Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 572 94. PMID: 17658511.
Mennerick et al (2004) Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors. Mol.Pharmacol. 65 1191. PMID: 15102947.
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Keywords: 17-PA, supplier, antagonists, neurosteroid, potentiation, direct, gating, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Modulator products