Cat. No. 2682
Alternative Names: 4-PB, Sodium phenylbutyrate
Chemical Name: 4-Phenylbutyric acid, sodium salt
Biological ActivityHistone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Khan et al (2011) HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 28 977. PMID: 21894430.
Ammerpohl et al (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 96 73. PMID: 17164759.
Appelskog et al (2004) Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 24 1419. PMID: 15138583.
Engelhard et al (1998) Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 37 97.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Sodium 4-Phenylbutyrate from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Sodium 4-Phenylbutyrate, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products