Cat. No. 2653
Alternative Name: NSC 303580
Chemical Name: 2-Phenylethynesulfonamide
Biological ActivityInhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kawamura et al (2009) Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 460 1140. PMID: 19668186.
Leu et al (2009) A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 36 15. PMID: 19818706.
Steele et al (2009) 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 114 1217. PMID: 19515722.
Strom et al (2006) Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2 474. PMID: 16862141.
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Citations are publications that use Tocris products. Selected citations for Pifithrin-μ include:
Blatzer et al (2015) Blocking Hsp70 Enhances the Efficiency of Amphotericin B Treatment against Resistant Aspergillus terreus Strains. Antimicrob Agents Chemother 59 3778. PMID: 25870060.
Xia et al (2014) EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int 2014 348728. PMID: 24745014.
Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. PLoS One 2013 857929. PMID: 23762164.
Kojima et al (2010) The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther 9 2545. PMID: 20736344.
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Keywords: Pifithrin-mu, supplier, inhibitors, inhibits, p53-mitochondrial, binding, Transcription, Factors, MDM2, p14ARF, Pifithrin-mu, NSC303580, Tocris Bioscience, p53 Inhibitor products