Co 101244 hydrochloride

Cat. No. 2456

Co 101244 hydrochloride C21H27NO3.HCl [193356-17-1]

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Alternative Names: PD 174494, Ro 63-1908

Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride

Biological Activity

Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Technical Data

M.Wt:
377.91
Formula:
C21H27NO3.HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
193356-17-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Higgins et al (2003) Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 44 324. PMID: 12604092.

Gill et al (2002) Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist. J.Pharmacol.Exp.Ther. 302 940. PMID: 12183650.

Zhou et al (1999) 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J.Med.Chem. 42 2993. PMID: 10425109.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Co 101244 hydrochloride include:

Quillinan et al (2015) Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. J Cell Biol 284 555. PMID: 25450957.

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Am J Physiol Renal Physiol 7 62. PMID: 25071439.

Peng et al (2008) TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Neuroscience 295 F1324. PMID: 18632800.

Do you know of a great paper that uses Co 101244 hydrochloride from Tocris? If so please let us know.

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Keywords: Co 101244 hydrochloride, supplier, selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Co101244, hydrochloride, PD174494, Ro63-1908, Tocris Bioscience, NMDA Receptor Antagonist products

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