Cat. No. 2828
Chemical Name: 2-(4-Morpholinyl)-4H-naphthol[1,2-b
Biological ActivityATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Amrein et al (2007) Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J.Pharmacol.Exp.Ther. 321 848. PMID: 17351105.
Hollick et al (2003) 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK). Bioorg.Med.Chem.Letts. 13 3083.
Veuger et al (2003) Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I. Cancer Res. 63 6008. PMID: 14522929.
If you know of a relevant reference for NU 7026 please let us know.
Citations are publications that use Tocris products. Selected citations for NU 7026 include:
Dolman et al (2015) DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS One 10 e0145744. PMID: 26716839.
Nakahara et al (2015) Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. Chembiochem 89 5040. PMID: 25717108.
You et al (2015) Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. Elife 4. PMID: 26437452.
Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13 408. PMID: 24247150.
Tang et al (2012) Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. J Neurosci 13 665. PMID: 22334513.
Bohgaki et al (2011) Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet 7 e1001381. PMID: 21552324.
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Keywords: NU 7026, supplier, Selective, DNA-dependent, protein, kinases, inhibitors, inhibits, DNA-PK, NU7026, Tocris Bioscience, DNA-Dependent Protein Kinase Inhibitor products
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