Cat. No. 2631
Alternative Names: BB 2516, Marimistat
Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(m
Biological ActivityBroad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151. PMID: 16083752.
Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431. PMID: 14524532.
Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69. PMID: 9364582.
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Citations are publications that use Tocris products. Selected citations for Marimastat include:
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382. PMID: 25365206.
Guo et al (2013) Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma. J Exp Clin Cancer Res 32 26. PMID: 23659326.
Mezil et al (2012) Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One 7 e43409. PMID: 23028451.
Kachgal and Putnam (2011) Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis 14 47. PMID: 21104120.
Ghajar et al (2010) Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res 316 813. PMID: 20067788.
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Keywords: Marimastat, supplier, Broad, spectrum, MMP, inhibitors, inhibits, Matrix, Metalloprotease, Matrixins, Metalloproteinase, proteinases, proteases, BB2516, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
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