Cat. No. 2631

Marimastat C15H29N3O5 [154039-60-8]

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Alternative Names: BB 2516, Marimistat

Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

Biological Activity

Broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151. PMID: 16083752.

Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431. PMID: 14524532.

Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69. PMID: 9364582.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Marimastat include:

Zariffard et al (2015) Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. Hum Reprod 10 e0116911. PMID: 25611319.

Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382. PMID: 25365206.

Brafman et al (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. PLoS One 20 369. PMID: 23154389.

Guo et al (2013) Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma. J Exp Clin Cancer Res 32 26. PMID: 23659326.

Li et al (2013) NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. J Biol Chem 28 2822. PMID: 23856325.

Mezil et al (2012) Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One 7 e43409. PMID: 23028451.

Prendergast et al (2012) The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Arthritis Res Ther 139 1141. PMID: 22296847.

Yurtsever et al (2012) Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. Development 287 42138. PMID: 23112050.

Kachgal and Putnam (2011) Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis 14 47. PMID: 21104120.

Ghajar et al (2010) Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res 316 813. PMID: 20067788.

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Keywords: Marimastat, supplier, Broad, spectrum, MMP, inhibitors, inhibits, Matrix, Metalloprotease, Matrixins, Metalloproteinase, proteinases, proteases, BB2516, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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