Cat. No. 2675
Chemical Name: N-[[[(1S)-1-Carboxy-3-methylbutyl]a
Biological ActivityPotent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.
Licensing InformationSold with the permission of Acenta Discovery, Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yamamoto et al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147. PMID: 17241276.
Zhou et al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015. PMID: 16341066.
Olszewski et al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876. PMID: 15140187.
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Keywords: ZJ 43, supplier, Glutamate, carboxypeptidase, II, III, NAALADase, NAAG, peptidase, inhibitors, inhibits, Carboxypeptidase, GCP, Peptidase, Proteinases, Proteases, ZJ43, Tocris Bioscience, Carboxypeptidase Inhibitor products