ZJ 43

Cat. No. 2675

ZJ 43 C12H20N2O7 [723331-20-2]

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Chemical Name: N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid

Biological Activity

Potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of  traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.

Licensing Information

Sold with the permission of Acenta Discovery, Inc.

Technical Data

M.Wt:
304.3
Formula:
C12H20N2O7
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
723331-20-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Yamamoto et al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147. PMID: 17241276.

Zhou et al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015. PMID: 16341066.

Olszewski et al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876. PMID: 15140187.

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Keywords: ZJ 43, supplier, Glutamate, carboxypeptidase, II, III, NAALADase, NAAG, peptidase, inhibitors, inhibits, Carboxypeptidase, GCP, Peptidase, Proteinases, Proteases, ZJ43, Tocris Bioscience, Carboxypeptidase Inhibitor products

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