NGB 2904

Cat. No. 2635

NGB 2904 C28H29Cl2N3O.HCl [189061-11-8]

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Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide

Biological Activity

Potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Technical Data

M.Wt:
530.92
Formula:
C28H29Cl2N3O.HCl
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
189061-11-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Pritchard et al (2007) The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 86 718. PMID: 17408730.

Xi et al (2006) The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31 1393. PMID: 16205781.

Yuan et al (1998) NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. Bioorg.Med.Chem.Lett. 8 2715. PMID: 9873609.

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Citations are publications that use Tocris products. Selected citations for NGB 2904 include:

Axel et al (2010) Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology 35 1464. PMID: 20200509.

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Keywords: NGB 2904, supplier, Potent, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, NGB2904, Tocris Bioscience, D3 Receptor Antagonist products

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