(S)-Norketamine hydrochloride

Cat. No. 6112

(S)-Norketamine hydrochloride C12H14ClNO.HCl [83777-70-2]

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Chemical Name: (S)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride

Biological Activity

NMDA receptor modulator. Metabolite of Ketamine hydrochloride (Cat. No.3131). Decreases intracellular D-serine concentration (IC50 = 62.4 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models. R-enantiomer and racemate also available.

Technical Data

M.Wt:
260.16
Formula:
C12H14ClNO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
83777-70-2

Resources

Other Information

R-enantiomer and racemate also available.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Singh et al (2016) Ketamine metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499. PMID: 27096720.

Holtman et al (2008) Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676. PMID: 18586315.

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Keywords: (S)-Norketamine hydrochloride, supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Tocris Bioscience, Ketamine and Metabolite products

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