CGP 71683 hydrochloride

Cat. No. 2199

CGP 71683 hydrochloride C26H29N5O2S.HCl [192322-50-2]

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Chemical Name: N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride

Biological Activity

Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

Technical Data

M.Wt:
512.07
Formula:
C26H29N5O2S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
192322-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Lecklin et al (2002) Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029. PMID: 11959807.

Dumont et al (2000) Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). Can.J.Physiol.Pharmacol. 78 116. PMID: 10737674.

Criscione et al (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J.Clin.Invest. 102 2136. PMID: 9854049.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 71683 hydrochloride include:

Reidelberger et al (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab 304 E944. PMID: 23482449.

Tilan et al (2013) Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects. Oncotarget 4 2487. PMID: 24318733.

Han et al (2012) Stress hormone epinephrine enhances adipogenesis in murine embryonic stem cells by up-regulating the neuropeptide Y system. PLoS One 7 e36609. PMID: 22570731.

Lu et al (2011) Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. J Biol Chem 286 27494. PMID: 21680731.

Do you know of a great paper that uses CGP 71683 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: CGP 71683 hydrochloride, supplier, selective, potent, non-peptide, NPY, Y5, receptor, antagonists, Neuropeptide, Y, Receptors, CGP71683, hydrochloride, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products

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