Cat. No. 2626
Alternative Names: NSC 241240, Paraplatin, JM 8
Chemical Name: cis-Diammine(1,1-cyclobutanedicarbo
Biological ActivityAntitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Thomas et al (2006) High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol.Pharmacol. 70 23. PMID: 16569706.
Natarajan et al (1999) Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 58 1625. PMID: 10535754.
Yang et al (1995) Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res. 143 302.
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Citations are publications that use Tocris products. Selected citations for Carboplatin include:
Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306. PMID: 26218638.
Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Cell Death Differ 14 570. PMID: 25104095.
Do you know of a great paper that uses Carboplatin from Tocris? If so please let us know.
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Keywords: Carboplatin, supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducer, Synthesis, NSC241240, chemotherapeutics, Tocris Bioscience, Apoptosis Inducing products