Cat. No. 2671
Chemical Name: (11β,16α)-16,17-[Butylidenebis(oxy)]-
Biological ActivitySynthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wattenberg et al (2007) Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res. 57 5489.
Pereira et al (2006) Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int.J.Cancer 120 1150.
Spencer et al (1995) Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease. Drugs 50 854. PMID: 8586030.
If you know of a relevant reference for Budesonide please let us know.
Citations are publications that use Tocris products. Selected citations for Budesonide include:
Kim et al (2016) Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Front Endocrinol (Lausanne) NULL me20161029. PMID: 27355192.
Liu et al (2015) A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Endocrinol 11 4121. PMID: 25672589.
Do you know of a great paper that uses Budesonide from Tocris? If so please let us know.
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Keywords: Budesonide, supplier, Synthetic, glucocorticoid, anti-inflammatory, chemopreventive, Receptors, Tocris Bioscience, Glucocorticoid Receptor products
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