Cat. No. 6107
Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl
Biological ActivityInhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691. PMID: 26422006.
Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187. PMID: 11561079.
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Keywords: CP 424174, supplier, CP424174, Inhibitor, IL-1, beta, post-translational, processing, β, NLRP3, inflammasomes, in, vivo, orally, bioavailable, Tocris Bioscience, Cytokine Inhibitor products