BMS 191011

Cat. No. 2665

BMS 191011 C16H10ClF3N2O3 [202821-81-6]

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Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Biological Activity

Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Technical Data

M.Wt:
370.71
Formula:
C16H10ClF3N2O3
Solubility:
Soluble to 100 mM in DMSO and to 15 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
202821-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Romine et al (2007) 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 50 528. PMID: 17266205.

Hewawasam et al (2003) Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts. 13 1695.

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Citations are publications that use Tocris products. Selected citations for BMS 191011 include:

Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101. PMID: 23653115.

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Keywords: BMS 191011, supplier, Potent, Maxi-K, channel, openers, BKCa, KCa11, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, BMS191011, activators, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Activator products

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