Cat. No. 2660
Alternative Name: R-L3
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1
Biological ActivityActivator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377. PMID: 22251082.
Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443. PMID: 16945016.
Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. PMID: 14576198.
Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses L-364,373 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: L-364,373, supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products
Find multiple products by catalog number
New Products in this Area
Potent and selective KV11.1 (hERG) channel blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.