L-364,373

Cat. No. 2660

L-364,373 C25H20FN3O [103342-82-1]

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Alternative Name: R-L3

Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

Biological Activity

Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.

Technical Data

M.Wt:
397.44
Formula:
C25H20FN3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
103342-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377. PMID: 22251082.

Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443. PMID: 16945016.

Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. PMID: 14576198.

Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220.

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Keywords: L-364,373, supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products

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