Cat. No. 2657
Chemical Name: 1-[2-Methoxy-4-(methylthio)benzoyl]
Biological ActivityPotent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395. PMID: 16847144.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JX 401 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JX 401, supplier, Potent, reversible, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, JX401, Tocris Bioscience, p38 MAPK Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective ERK5 inhibitorEicosapentaenoic Acid
Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylationBIRB 796
High affinity and selective p38 kinase inhibitorPH 797804
Potent and selective p38α/β inhibitor
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands