JX 401

Cat. No. 2657

JX 401 C21H25NO2S [349087-34-9]

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Chemical Name: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine

Biological Activity

Potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

Technical Data

M.Wt:
355.49
Formula:
C21H25NO2S
Solubility:
Soluble to 75 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
349087-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395. PMID: 16847144.

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Keywords: JX 401, supplier, Potent, reversible, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, JX401, Tocris Bioscience, p38 MAPK Inhibitor products

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