Compound W

Cat. No. 2654

Compound W C19H12N2O8 [173550-33-9]

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Alternative Name: CW

Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid

Biological Activity

Inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).

Technical Data

M.Wt:
396.31
Formula:
C19H12N2O8
Solubility:
Soluble to 50 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
173550-33-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Okochi et al (2006) Secretion of the notch-1 Aβ-like peptide during notch signaling. J.Biol.Chem. 281 7890. PMID: 16434391.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Compound W include:

Greife et al (2014) Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer 14 628. PMID: 25167871.

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Keywords: Compound W, supplier, γ-secretase, gamma-secretase, inhibitors, reduces, Aβ4, β42, beta42, levels, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, CompoundW, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, γ-Secretase Inhibitor products

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