Cat. No. 2654
Alternative Name: CW
Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid
Biological ActivityInhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Okochi et al (2006) Secretion of the notch-1 Aβ-like peptide during notch signaling. J.Biol.Chem. 281 7890. PMID: 16434391.
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Citations are publications that use Tocris products. Selected citations for Compound W include:
Greife et al (2014) Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer 14 628. PMID: 25167871.
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Keywords: Compound W, supplier, γ-secretase, gamma-secretase, inhibitors, inhibits, reduces, Aβ4, β42, beta42, levels, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, CompoundW, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, γ-Secretase Inhibitor products
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