Cilnidipine

Cat. No. 2629

Cilnidipine C27H28N2O7 [132203-70-4]

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Alternative Name: FRC 8653

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Technical Data

M.Wt:
492.52
Formula:
C27H28N2O7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
132203-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Nap et al (2004) The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. Fund.Clin.Pharmacol. 18 309.

Takahara et al (2004) Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model. Biol.Pharm.Bull. 27 1388. PMID: 15340224.

Murai et al (2000) Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 854 6. PMID: 10784100.

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Keywords: Cilnidipine, supplier, Ca2+, channel, blockers, dual, L/N-type, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, FRC8653, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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