SB 3CT

Cat. No. 6088new

SB 3CT C15H14O3S2 [292605-14-2]

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Chemical Name: 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane

Biological Activity

Selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.

Technical Data

M.Wt:
306.4
Formula:
C15H14O3S2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
292605-14-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3 730. PMID: 23077716.

Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 25 6401. PMID: 16000631.

Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 18 17125. PMID: 11278946.

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Citations are publications that use Tocris products.

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Keywords: SB 3CT, supplier, SB3CT, Selective, high, affinity, MMP2, inhibitors, MMP9, blood-brain, barrier, BBB, permeable, matrix, metalloproteinases, neuroprotective, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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