Cat. No. 2625

Zonisamide C8H8N2O3S [68291-97-4]

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Alternative Names: AD 810, CI 912

Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide

Biological Activity

Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Technical Data

Soluble to 10 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98. PMID: 17255467.

Gluck et al (2004) Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713. PMID: 15168218.

Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683. PMID: 14704463.

Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. Neurochem.Res. 25 1107. PMID: 11055748.

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Citations are publications that use Tocris products.

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Keywords: Zonisamide, supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, peroxidation, scavenges, hydroxyl, nitric, oxide, free, radicals, scavenger, Tocris Bioscience, Other Channel Modulator products

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