Bay 36-7620

Cat. No. 2501

Bay 36-7620 C19H18O2 [232605-26-4]

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Chemical Name: (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one

Biological Activity

Selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.

Licensing Information

Sold for research purposes under agreement from Bayer

Technical Data

M.Wt:
278.35
Formula:
C19H18O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
232605-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Gil-Sanz et al (2007) Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb.Cortex 18 1653. PMID: 18024992.

Carroll et al (2001) BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol.Pharmacol. 59 965. PMID: 11306677.

De Vry et al (2001) Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620. Eur.J.Pharmacol. 428 203. PMID: 11675037.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Bay 36-7620 include:

Veettil et al (2014) Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog 10 e1004389. PMID: 25299066.

Wall et al (2014) Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res 27 263. PMID: 24330389.

Le et al (2010) The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol 130 2240. PMID: 20505744.

Tronson et al (2010) Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Autophagy 68 1007. PMID: 21075228.

Do you know of a great paper that uses Bay 36-7620 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

Keywords: Bay 36-7620, supplier, Bay367620, selective, non-competitive, mGlu1, mGluR1, antagonists, receptors, inverse, agonists, metabotropic, glutamate, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products

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