ARP 101

Cat. No. 2622

ARP 101 C20H26N2O5S [849773-63-3]

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Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide

Biological Activity

Selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).

Technical Data

M.Wt:
406.5
Formula:
C20H26N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
849773-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260. PMID: 16483784.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ARP 101 include:

Rocha-Azevedo et al (2015) PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2. Hum Reprod 26 1098. PMID: 25589674.

Li et al (2013) NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Oncotarget 28 2822. PMID: 23856325.

Do you know of a great paper that uses ARP 101 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: ARP 101, supplier, inhibitors, inhibits, MMP-2, Matrix, Metalloprotease, Matrixins, Metalloproteinase, MMP, Proteinases, Proteases, ARP101, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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