ARP 100

Cat. No. 2621

ARP 100 C17H20N2O5S [704888-90-4]

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Chemical Name: 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide

Biological Activity

Selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.

Technical Data

M.Wt:
364.42
Formula:
C17H20N2O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
704888-90-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260. PMID: 16483784.

Rossello et al (2004) New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg.Med.Chem. 12 2441. PMID: 15080939.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ARP 100 include:

Hensley et al (2012) Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 14 451. PMID: 22787427.

Chetty et al (2010) MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Mol Biol Cell 127 1081. PMID: 20027628.

Do you know of a great paper that uses ARP 100 from Tocris? If so please let us know.

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Keywords: ARP 100, supplier, Selective, inhibitors, inhibits, MMP-2, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, ARP100, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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