AG 879

Cat. No. 2617

AG 879 C18H24N2OS [148741-30-4]

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Alternative Name: Tyrphostin AG 879

Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide

Biological Activity

Inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).

Technical Data

M.Wt:
316.46
Formula:
C18H24N2OS
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
148741-30-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rende et al (2006) Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs 17 929. PMID: 16940803.

He et al (2004) The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol.Ther. 3 96. PMID: 14726663.

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Keywords: AG 879, supplier, AG879, tyrosine, kinase, inhibitors, ErbB2, VEGFR-2, EGFR, Flk-1, nerve, growth, factors, inhibits, NGF, TrkA, Tocris Bioscience, Trk Receptor Inhibitor products

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