Apamin

Cat. No. 1652

Apamin Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bridges: 1 - 11, 3 - 15)

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Biological Activity

Prototypical potent and highly selective inhibitor of the small-conductance Ca2+-activated K+-channel (KCa2, SK). Blocks medium after-hyperpolarization in vitro and is brain penetrant and convulsive in vivo.

Technical Data

M.Wt:
2027.34
Formula:
C79H131N31O24S4
Sequence:
CNCKAPETALCARRCQQH

(Modifications: Disulfide bridge between 1 - 11, 3 - 15, His-18 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
24345-16-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Stocker et al (2004) Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations. Toxicon 43 933. PMID: 15208027.

van der Staay et al (1999) Behavioral effects of apamin, a selective inhibitor of the SKCa-channel, in mice and rats. Neurosci.Biobehav.Rev. 23 1087. PMID: 10643819.

Strong (1990) Potassium channel toxins. Pharmacol.Ther. 46 137. PMID: 2181489.

Habermann (1984) Apamin. Pharmacol.Ther. 25 255. PMID: 6095335.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Apamin include:

Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701. PMID: 26134652.

Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154. PMID: 23646190.

Turker et al (2013) Amiodarone inhibits apamin-sensitive potassium currents. PLoS One 8 e70450. PMID: 23922993.

Few et al (2012) Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 109 E452. PMID: 22308469.

Geier et al (2011) Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels. Am J Physiol Cell Physiol 300 C937. PMID: 21228322.

Meredith et al (2011) Postnatal expression of an apamin-sensitive k(ca) current in vestibular calyx terminals. J Membr Biol 244 81. PMID: 22057903.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Do you know of a great paper that uses Apamin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Apamin, supplier, K+, channels, blockers, small, conductance, ca2+-activated, ca2+-dependent, Potassium, KCa, KCa2, SK, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Blocker products

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