Cat. No. 2613
Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)az
Biological ActivityPotent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Redonde et al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476. PMID: 17892531.
Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789. PMID: 17659592.
Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562. PMID: 16717135.
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Citations are publications that use Tocris products. Selected citations for NSC 87877 include:
Abeyweera et al (2011) Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol 192 675. PMID: 21339333.
Fragale et al (2011) Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol 186 1951. PMID: 21220691.
Quintanar-Audelo et al (2011) Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. J Biol Chem 286 23102. PMID: 21531714.
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Keywords: NSC 87877, supplier, Potent, inhibitors, inhibits, shp2, shp1, PTP, Protein, Tyrosine, Phosphatases, NSC87877, Tocris Bioscience, Protein Tyrosine Phosphatases Inhibitor products
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