MRS 1706

Cat. No. 1584

MRS 1706 C27H29N5O5 [264622-53-9]

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Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide

Biological Activity

Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).

Licensing Information

Manufactured and sold under license from Adenosine Therapeutics, LLC

Technical Data

M.Wt:
503.56
Formula:
C27H29N5O5
Solubility:
Soluble to 5 mM in DMSO
Purity:
>96 %
Storage:
Store at +4°C
CAS No:
264622-53-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Li et al (2007) ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J.Pharmacol.Exp.Ther. 320 637. PMID: 17077318.

Kiec-Kononowicz et al (2001) New developments in A1 and A2 adenosine receptor antagonists. Pure Appl.Chem. 73 1411.

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165. PMID: 10737749.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for MRS 1706 include:

Eusemann et al (2015) Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One 10 e0134934. PMID: 26263491.

Li et al (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci 31 237. PMID: 24844306.

Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144. PMID: 24050945.

Mandapathil et al (2010) Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem 285 7176. PMID: 19858205.

Schneider et al (2010) Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J 24 70. PMID: 19720619.

Clark et al (2009) Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci 29 11237. PMID: 19741130.

Epperson et al (2009) Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol 296 C1171. PMID: 19244482.

Xi et al (2009) Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol 47 684. PMID: 19695259.

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Keywords: MRS 1706, supplier, Potent, selective, A2B, inverse, agonists, Receptors, adenosines, MRS1706, Tocris Bioscience, A2B Receptor Antagonist products

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