Cat. No. 6077new

DETA NONOate C4H13N5O2 [146724-94-9]

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Chemical Name: 2,2'-(2-Hydroxy-2-nitrosohydrazinylidene)bis-ethanamine

Biological Activity

Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.

Technical Data

Soluble to 100 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Thompson et al (2009) The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br.J.Pharmacol. 158 1338. PMID: 19785659.

Wegener et al (2002) Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 136 415. PMID: 12023944.

Olson et al (1997) Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29 254. PMID: 9039111.

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Keywords: DETA NONOate, supplier, nitric, oxide, releasing, compounds, donors, NO, Tocris Bioscience, NO Donors / Precursor products

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