Cat. No. 6068
Chemical Name: N-Methyl-N-[3-(3-methyl-1,2,4-triaz
Biological ActivityRNA binding protein Lin28 inhibitor (IC50 = 8 μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Also bromodomain inhibitor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773. PMID: 27548809.
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Keywords: Lin28 1632, supplier, Lin281632, RNA-binding, protein, Lin28, stem, cell, differentiation, bromodomains, inhibitors, inhibits, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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