Cat. No. 6068
Chemical Name: N-Methyl-N-[3-(3-methyl-1,2,4-triaz
Biological ActivityRNA binding protein Lin28 inhibitor (IC50 = 8 μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Also bromodomain inhibitor.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773. PMID: 27548809.
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Keywords: Lin28 1632, supplier, Lin281632, RNA-binding, protein, Lin28, stem, cell, differentiation, bromodomains, inhibitors, inhibits, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products