LDN 193189 dihydrochloride
Cat. No. 6053
Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyraz
Biological ActivityPotent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).
Licensing InformationSold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Li et al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270. PMID: 24012368.
Chambers et al (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat.Biotechnol. 30 715. PMID: 22750882.
Cuny et al (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg.Med.Chem.Lett. 18 4388. PMID: 18621530.
Yu et al (2008) BMP type I receptor inhibition reduces heterotopic ossification. Nat.Med. 14 1363. PMID: 19029982.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses LDN 193189 dihydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LDN 193189 dihydrochloride, supplier, LDN193189, dihydrochloride, BMP, signaling, ALK2, ALK3, activin, bone, morphogenetic, proteins, stem, cells, neural, differentiation, neurons, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products
Find multiple products by catalog number
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands