LDN 193189 dihydrochloride

Cat. No. 6053new

LDN 193189 dihydrochloride C25H22N6.2HCl [1435934-00-1]

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Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride

Biological Activity

Potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484

Technical Data

M.Wt:
479.4
Formula:
C25H22N6.2HCl
Solubility:
Soluble to 50 mM in water and to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1435934-00-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Li et al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270. PMID: 24012368.

Chambers et al (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat.Biotechnol. 30 715. PMID: 22750882.

Cuny et al (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg.Med.Chem.Lett. 18 4388. PMID: 18621530.

Yu et al (2008) BMP type I receptor inhibition reduces heterotopic ossification. Nat.Med. 14 1363. PMID: 19029982.

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Keywords: LDN 193189 dihydrochloride, supplier, LDN193189, dihydrochloride, BMP, signaling, ALK2, ALK3, activin, bone, morphogenetic, proteins, stem, cells, neural, differentiation, neurons, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products

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