BAY 58-2667 hydrochloride

Cat. No. 6052

BAY 58-2667 hydrochloride C36H39NO5.HCl [646995-35-9]

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Alternative Name: Cinaciguat hydrochloride

Chemical Name: 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride

Biological Activity

Potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Roy et al (2008) Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 153 1495. PMID: 18204474.

Stasch et al (2006) Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 116 2552. PMID: 16955146.

Stasch et al (2002) NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 136 773. PMID: 12086987.

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