AS 8351

Cat. No. 6044

AS 8351 C17H13N3O2 [796-42-9]

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Chemical Name: 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone

Biological Activity

Induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409. Iron chelator and putative inhibitor of KDM5B.

Technical Data

M.Wt:
291.3
Formula:
C17H13N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
796-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 6290. PMID: 27127239 .

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Keywords: AS 8351, supplier, AS8351, stem, cells, cardiac, cardiomyocytes, reprogramming, iron, chelators, reprogramming, differentiation, KDM, Tocris Bioscience, Reprogramming products

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Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

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