Cat. No. 6043
Alternative Names: BML 284, CID 11210285
Chemical Name: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(
Biological ActivityWnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9. PMID: 27207629.
Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61. PMID: 26613980.
Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266. PMID: 23405280.
Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987. PMID: 15724259.
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Keywords: AMBMP hydrochloride, supplier, BML284, CID11210285, wnt, canonical, signaling, pathway, activators, activates, tublulin, polymerization, inhibitors, inhibits, Tocris Bioscience, Other Wnt Signaling Activator products
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