(R)-MG 132

Cat. No. 6033new

(R)-MG 132 C26H41N3O5 [1211877-36-9]

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Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

Biological Activity

Potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.

Technical Data

M.Wt:
475.63
Formula:
C26H41N3O5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1211877-36-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mroczkiewicz et al (2010) Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 53 1509. PMID: 20112914.

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Keywords: (R)-MG 132, supplier, (R)-MG132, 20S, proteasome, inhibitors, inhibits, potent, Tocris Bioscience, Proteasome Inhibitor products

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