Oleanolic acid

Cat. No. 6026

Oleanolic acid C30H48O3 [508-02-1]

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Chemical Name: (3β)-3-Hydroxyolean-12-en-28-oic acid

Biological Activity

GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.

Technical Data

M.Wt:
456.7
Formula:
C30H48O3
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
508-02-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mu et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864. PMID: 26823699.

Castellano et al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791. PMID: 23704520.

Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178. PMID: 19911773.

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Citations are publications that use Tocris products.

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Keywords: Oleanolic acid, supplier, Natural, triterpenoids, TGR5, partial, agonists, agonism, protein, phosphate, 1B, PTP1B, inhibitors, inhibits, glycogen, phosphorylases, antidiabetic,, antihyperglycaemic, antitumor, hepatoprotective, apoptosis, inducers, cell, proliferation, Tocris Bioscience, GPBA Receptor Agonist products

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