Oleanolic acid

Cat. No. 6026

Oleanolic acid C30H48O3 [508-02-1]

Price and Availability

For Oleanolic acid pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (3β)-3-Hydroxyolean-12-en-28-oic acid

Biological Activity

GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.

Technical Data

M.Wt:
456.7
Formula:
C30H48O3
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
508-02-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mu et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864. PMID: 26823699.

Castellano et al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791. PMID: 23704520.

Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178. PMID: 19911773.

If you know of a relevant reference for Oleanolic acid please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Oleanolic acid from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Oleanolic acid, supplier, Natural, triterpenoids, TGR5, partial, agonists, agonism, protein, phosphate, 1B, PTP1B, inhibitors, inhibits, glycogen, phosphorylases, antidiabetic,, antihyperglycaemic, antitumor, hepatoprotective, apoptosis, inducers, cell, proliferation, Tocris Bioscience, GPBA Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Insulin Signaling Pathway

Insulin Signaling Pathway

Signals through the insulin pathway are fundamental for the regulation of intracellular glucose levels. View pathway or download PDF today.

divider line

New Products in this Area

Prasugrel

Irreversible P2Y12 antagonist; antiplatelet and orally active

BigLEN (rat)

Potent GPR171 agonist

BigLEN (mouse)

GPR171 agonist

BPTU

P2Y1 allosteric antagonist

AC 265347

CaSR biased allosteric modulator

7α,25-Dihydroxycholesterol

Highly potent GPR183 (EBI2) agonist

AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

FTY 720

Potent S1P receptor agonist; also immunosuppressant

Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

UMB 68

GHB receptor ligand

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennial Meeting

August 20 - 24, 2017

Paris , France

Booth: 11