Cat. No. 6020
Chemical Name: N-[1,1'-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
Biological ActivityNon-competitive MAGL inhibitor. Exhibits selectivity for MAGL over FAAH, diacylglycerol lipase and COX2. Blocks 2-AG hydrolysis in rat brain slices. Enhances stress-induced analgesia in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature. 435 1108. PMID: 15973410.
Makara et al (2005) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat.Neurosci. 8 1139. PMID: 16116451.
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Keywords: URB 602, supplier, URB602, non-competitive, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products