URB 602

Cat. No. 6020new

URB 602 C19H21NO2 [565460-15-3]

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Chemical Name: N-[1,1'-Biphenyl]-3-yl-carbamic acid cyclohexyl ester

Biological Activity

Non-competitive MAGL inhibitor. Exhibits selectivity for MAGL over FAAH, diacylglycerol lipase and COX2. Blocks 2-AG hydrolysis in rat brain slices. Enhances stress-induced analgesia in rats.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature. 435 1108. PMID: 15973410.

Makara et al (2005) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat.Neurosci. 8 1139. PMID: 16116451.

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Keywords: URB 602, supplier, URB602, non-competitive, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, Tocris Bioscience, Monoacylglycerol Lipase Inhibitor products

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