Cat. No. 6019
Alternative Name: Ile-Pro-Ile
Chemical Name: L-Isoleucyl-L-prolyl-L-isoleucine
Biological ActivityDipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Lee et al (2016) Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 6 29393. PMID: 27381080.
Lim et al (2015) Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 30 759. PMID: 26552451.
Juillerat-Jeanneret et al (2014) Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 57 2197. PMID: 24099035.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Diprotin A from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Diprotin A, supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, type, 2, diabetes, hematopoietic, stem, cells, HSCs, vascular, permeability, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products
Find multiple products by catalog number
New Products in this Area
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.