Diprotin A

Cat. No. 6019

Diprotin A C17H31N3O4 [90614-48-5]

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Alternative Name: Ile-Pro-Ile

Chemical Name: L-Isoleucyl-L-prolyl-L-isoleucine

Biological Activity

Dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.

Technical Data

Soluble to 100 mM in water
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lee et al (2016) Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 6 29393. PMID: 27381080.

Lim et al (2015) Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 30 759. PMID: 26552451.

Juillerat-Jeanneret et al (2014) Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 57 2197. PMID: 24099035.

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Citations are publications that use Tocris products.

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Keywords: Diprotin A, supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, type, 2, diabetes, hematopoietic, stem, cells, HSCs, vascular, permeability, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products

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