Cat. No. 6019
Alternative Name: Ile-Pro-Ile
Chemical Name: L-Isoleucyl-L-prolyl-L-isoleucine
Biological ActivityDipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lee et al (2016) Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 6 29393. PMID: 27381080.
Lim et al (2015) Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 30 759. PMID: 26552451.
Juillerat-Jeanneret et al (2014) Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 57 2197. PMID: 24099035.
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Keywords: Diprotin A, supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, type, 2, diabetes, hematopoietic, stem, cells, HSCs, vascular, permeability, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products
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