Cat. No. 6015
Alternative Name: CHIR 265
Chemical Name: 1-Methyl-5-[[2-[5-(trifluoromethyl)
Biological ActivityRaf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Chen et al (2011) Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res. 71 4280. PMID: 21527556 .
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Keywords: RAF 265, supplier, RAF265, Raf, kinases, inhibitors, inhibits, B-Raf, c-Raf, VEGFR2, vascular, endothelial, growth, factor, cytotoxic, MAPK, Tocris Bioscience, Raf Kinase Inhibitor products
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