Cat. No. 6011
Biological ActivityTLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R/
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859. PMID: 27258267.
Mauldin et al (2015) TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386. PMID: 25765738.
Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657. PMID: 14977973.
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Keywords: FSL 1, supplier, FSL1, TLR2/6, agonists, agonism, putative, TLR10, ligands, Toll-like, receptors, induces, inducers, TNF-α, TNF-alpha, TNF-a, tumor, tumour, necrosis, factor, NFκB, NFKB, HGF, Tocris Bioscience, Toll-like Receptor Agonist products
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