FSL 1

Cat. No. 6011

FSL 1 Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe

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Biological Activity

TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Technical Data

M.Wt:
1666.16
Formula:
C84H140N14O18S
Sequence:
CGDPKHPKSF

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
322455-70-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859. PMID: 27258267.

Mauldin et al (2015) TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386. PMID: 25765738.

Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657. PMID: 14977973.

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Citations are publications that use Tocris products.

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Keywords: FSL 1, supplier, FSL1, TLR2/6, agonists, agonism, putative, TLR10, ligands, Toll-like, receptors, induces, inducers, TNF-α, TNF-alpha, TNF-a, tumor, tumour, necrosis, factor, NFκB, NFKB, HGF, Tocris Bioscience, Toll-like Receptor Agonist products

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