BRD 4354

Cat. No. 6010

BRD 4354 C21H23ClN4O [315698-07-8]

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Chemical Name: 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol

Biological Activity

HDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.

Technical Data

M.Wt:
382.89
Formula:
C21H23ClN4O
Solubility:
Soluble to 20 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
315698-07-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Boskovic et al (2016) Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. ACS Chem.Biol. 11 1844. PMID: 27064299.

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Citations are publications that use Tocris products.

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Keywords: BRD 4354, supplier, BRD4354, HDAC5, HDAC9, selective, histone, deacetylases, inhibitors, inhibits, Tocris Bioscience, Histone Deacetylase Inhibitor products

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