Cat. No. 6010
Chemical Name: 5-Chloro-7-[(4-ethyl-1-piperazinyl)
Biological ActivityHDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Boskovic et al (2016) Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. ACS Chem.Biol. 11 1844. PMID: 27064299.
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Keywords: BRD 4354, supplier, BRD4354, HDAC5, HDAC9, selective, histone, deacetylases, inhibitors, inhibits, Tocris Bioscience, Histone Deacetylase Inhibitor products
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Potent class I and IIb HDAC inhibitor
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands