INCB 024360-analog

Cat. No. 6007

INCB 024360-analog C9H7ClFN5O2 [914471-09-3]

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Chemical Name: 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Biological Activity

Potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.

Technical Data

M.Wt:
271.64
Formula:
C9H7ClFN5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
914471-09-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Weinmann (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450. PMID: 26836578.

Dounay et al (2015) Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 58 8762. PMID: 26207924.

Yue et al (2009) Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 52 7364. PMID: 19507862.

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Citations are publications that use Tocris products.

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Keywords: INCB 024360-analog, supplier, 1, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, Tocris Bioscience, Indoleamine 2,3 dioxygenase Inhibitor products

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