Acein

Cat. No. 6006

Acein Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala

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Biological Activity

High affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.

Technical Data

M.Wt:
932.5
Formula:
C43H68N10O13
Sequence:
PPTTTKFAA
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Neasta et al (2016) The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release. Br.J.Pharmacol. 173 1314. PMID: 27027724 .

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Keywords: Acein, supplier, High, affinity, angiotensin, converting, enzymes, ACE, ligands, Tocris Bioscience, Angiotensin-Converting Enzyme Ligand products

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