Cat. No. 6001
Chemical Name: 2-(Hexylthio)-6-hydroxy-4(3H)-pyrim
Biological ActivitySelective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 uM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579. PMID: 27326330.
Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337. PMID: 26962172 .
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Keywords: ZQ 16, supplier, ZQ16, selective, medium, chain, free, fatty, acid, receptor, GPR84, agonists, agonism, Tocris Bioscience, Free Fatty Acid Receptor Agonist products
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