Cat. No. 6000
Chemical Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-
Biological ActivityPotent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo. Negative control TP 472N (Cat. No. 5999) available.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hohmann and Vakoc et al (2014) A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 30 356. PMID: 24932742.
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Citations are publications that use Tocris products.
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Keywords: TP 472, supplier, TP472, bromodomains, BRD9, BRD7, inhibitors, potent, Tocris Bioscience, Bromodomain Inhibitor products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.