Cat. No. 5992
Biological ActivityPotent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells.
(Modifications: Disulfide bridge: 1-6,9-14)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017. PMID: 21560248.
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Keywords: MM 54, supplier, MM54, potent, apelin, receptors, antagonists, antagonism, Tocris Bioscience, Apelin Receptor Antagonist products
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