Cat. No. 5992
Biological ActivityPotent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells.
(Modifications: Disulfide bridge: 1-6,9-14)
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017. PMID: 21560248.
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Keywords: MM 54, supplier, MM54, potent, apelin, receptors, antagonists, antagonism, Tocris Bioscience, Apelin Receptor Antagonist products
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