MM 54

Cat. No. 5992new

MM 54 Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys

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Biological Activity

Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells.

Technical Data

M.Wt:
1737.15
Formula:
C70H121N29O15S4
Sequence:
CRPRLCKHCRPRLC

(Modifications: Disulfide bridge: 1-6,9-14)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1313027-43-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017. PMID: 21560248.

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Keywords: MM 54, supplier, MM54, potent, apelin, receptors, antagonists, antagonism, Tocris Bioscience, Apelin Receptor Antagonist products

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